For these, please consult a doctor (virtually or in person). 2001;94:1536. These results all indicate that HPV positivity does not have much impact on the overall survival of DLBCL patients. Doctors typically provide answers within 24 hours. Three patients (cases 1, 2, 7) received R-CHOP, 3 (cases 46) patients received CHOP, and 1 patient (case 3) received GDP and CHOP therapy. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. Six of the cases exhibited tongue base masses with smooth surface membranes. The cortex is also divided into outer cortex and inner cortex (also known as the paracortex). [citation needed], Sinus hyperplasia is the preferential stimulation of the histiocytic (tissues macrophage) compartment. For T cell receptor rearrangement, the IdentiClone TCRB, TCRG, and TCRD Gene Clonality Assays were used with gel detection (InVivoScribe Technologies, San Diego, CA, USA). Ezzat AA, Ibrahim EM, El Weshi AN, Khafaga YM, AlJurf M, Martin JM, Ajarim DS, Bazarbashi SN, Stuart RK, Zucca E. Localized non-Hodgkin's lymphoma of Waldeyer's ring: clinical features, management, and prognosis of 130 adult patients. 2010;77:96105. FOIA Bookshelf 2017;118:6028. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot potato voice' dysphonia. Article Rinsho Ketsueki. When the lymphoid tissue is deeply seated, the appearance may be more pink or deeper in color. Oral-cutaneous CD4-positive T-cell lymphoma: a study of two patients. This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. https://doi.org/10.1002/cncr.27988. https://doi.org/10.1097/01.dad.0000246949.49071.17. Before 1991;6(3):170-8. doi: 10.1007/BF02493520. For NHL of the head and neck, there is a logarithmic increase in incidence with increasing age [18] .The average age at disease diagnosis was 61.8years and there were no observed gender differences. In special cases, several biopsies are needed. The follicles are cytologically polymorphous, are often polarized, and vary in size and shape. As always, continue to ask good questions and listen to what your patients are telling you! Tumour cells expressed CD3, CD4, and CD5. Cancer that develops in the base of the tongue is a type of head and neck cancer. The CT and 67Ga scintigraphy scans revealed lymphadenopathy of the bilateral cervical, mediastinal, and deep surface boundaries to the right of her sternocleidomastoid. Harabuchi Y, Tsubota H, Ohguro S, Himi T, Asakura K, Kataura A, Ohuchi A, Hareyama M. Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring. When oral aggregates appear in clusters or have an unusual appearance or enlargement, clinicians may question whether abnormalities are present. Some cases of DLBCL may be associated with HPV infection. c. Some tumour cells were medium-sized with a clear cytoplasm (200x). The https:// ensures that you are connecting to the CAS Globus pharyngeus: a review of its etiology, diagnosis and treatment. Except in one case of four, all of our patients were alive through follow-up. Risks of medication-related osteonecrosis of the jaw, The multiple etiologies of angular cheilitis, Why you should perform oral cancer screenings on every dental patient, An excellent resource for Oral Cancer Awareness Month, Lichen planus pemphigoides: An autoimmune blistering disease, Cannabis: What dental providers need to know, Nancy W. Burkhart, EdD, MEd, BSDH, AAFAAOM. Lopez-Guillermo et al. Expression and alteration of p16 in diffuse large B cell lymphoma. 2004;103:27582. Work-up of globus: assessing the benefits of neck ultrasound and videofluorography. Severe benign LH is unusual in the head and neck region, but the diagnosis should be entertained on the part of the clinician both clinically and histologically when lymphoma is suspectedparticularly in the oral cavity. Four treatment response classes were defined, as follows: complete response (CR, 100% resolution); partial response (PR, 50100% resolution); no response (<50% resolution); and progression of disease (PD, tumour enlarged after treatment). Four out of five of the DLBCL cases were NOS subtypes. In the literature, the patients with peripheral T cell lymphoma of the tongue base were middle aged with no obvious differences in gender distribution. Methods We reported a severe case of tongue base BLH compromising the breathing and swallowing of the affected patient. 2006;45:25871. 4th ed. PubMed Copyright 2011 Noah B. Sands and Marc Tewfik. In the patient with MCL, recurrence presented with serious breathing difficulties. While an association with bacterial infection has not been clearly identified, one aggressive case of FLH has been linked to the presence of Epstein-Barr virus, causing clonal arrangement (expansion) in the local tissue DNA [4]. EBV ISH was performed using EBV-encoded Small RNA (EBER) probes (Bond ready-to-use ISH, Catalogue No: PB0589, Leica Biosystems Newcastle, Ltd.) according to the manufacturers protocol. Bethesda, MD 20894, Web Policies doi: 10.1148/radiology.144.4.7111732. The mean size is 2.5cm in the literature (range 15cm). MeSH Mitosis could be observed easily. Unauthorized use of these marks is strictly prohibited. Mamede RC, De Mello-Filho FV, Vigrio LC, Dantas RO. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China. Two patients, including our patient, died during follow-up. Spontaneous regression has also been reported. For DNA detection of high-riskin situ HPV infection, biotin-labelled HPV probe solutions (Leica, Newcastle, UK) were added to formalin-fixed, paraffin-embedded tissue sections. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). Feinberg SM, Ou SH, Gu M, Shibuya TY. Cite this article. 1997;36:41320. The HPV ISH positive case also had diffuse and strong expression of P16 protein as revealed by IHC, besides, HPV RNA ISH in this case is negative (Fig. Positive nucleolus staining was used to identify Bcl-6, mum-1, CyclinD1, SOX11 and Ki-67. Lopez-Guillermo A, Colomo L, Jimenez M, Bosch F, Villamor N, Arenillas L, Muntanola A, Montoto S, Gine E, Colomer D, Bea S, Campo E, Montserrat E. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. ZL, BW, XR and YC reviewed all the cases together. https://doi.org/10.1053/ajot.2000.8382. The lingual tonsil is located at the base of the tongue and related to circumvallate papillae, whereas subepithelial lymphoid tissue at the posterior lateral portion of the tongue and related to foliate papillae constitutes the lateral lingual tonsil. Ann Diagn Pathol. It tends to present as a unilateral, painless, slow-growing, nonulcerated mass. Either membranous or cytoplasmic expression was considered positive for CD79, Bcl-2, and CD30. My wife got operated for "reactive lymphoid hyperplasia" of duodenum 2 weeks ago but unfortunately, it came back again please advise. Spectrum of a benign entity Radiology. Authors M Gromet , M J Homer , B L Carter PMID: 7111732 DOI: 10.1148/radiology.144.4.7111732 No abstract available Publication types Case Reports MeSH terms Adult Barium Sulfate Deglutition Diagnosis, Differential Female Bone marrow biopsy is necessary to rule out CNS involvement. DNA was extracted from paraffin-embedded tissue using standard DNA isolation kits (QIAGEN, 56404). 2005;23:2797804. https://doi.org/10.1080/02841860500531682. Patient ages ranged from the thirties to the nineties, with an average age of 61.8years. J Laryngol Otol. Immunohistochemistry was negative for lymphoma. 1999;21:24754. Radiology. Patients first experienced from varying degrees of throat discomfort and commit to the hospital with no B symptoms. All authors read and approved the final manuscript. 2017;18:27815. Histologically, there was a monomorphous population of intermediate- to large-sized lymphocytes with slightly irregular indented nuclei and moderately dispersed chromatin (Fig. Oral and Maxillofacial Pathology. A 64-year-old African Canadian female with a history of urinary incontinence was admitted for an elective bladder suspension procedure by the gynaecology service in our institution. 88, no. Three patients were at an early stage (stage I and II) and had low IPI scores (0 or 1). At the time of manuscript preparation, there were only four articles indexed in Medline that described PTCL and tongue involvement (Table 4, [12,13,14,15]). Bone marrow involvement was identified at relapse. 2000;46:2112. Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. c. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (40 x) d. Immunohistochemistry staining showed diffuse and strong staining of P16 protein (100 x). 2023 Endeavor Business Media, LLC. Microorganisms that are regularly associated with the development of NHL include EBV, HIV,etc. https://doi.org/10.1007/s12185-008-0142-z. Patricia Uherova et al. Please enable it to take advantage of the complete set of features! World J Gastroenterol. Imaging and pathological findings of DLBCL (case 5). 8600 Rockville Pike All rights reserved. Do foreign bodies migrate through the body towards the heart? Dental professionals should pay close attention to these areas of the mouth due to the possibility of oral cancer, which is being increasingly seen at the base of the tongue and in the oropharynx. Manage cookies/Do not sell my data we use in the preference centre. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. Cytoplasmic composition also varied between cases, from abundant to scant. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. 2014;118:33847. Xinyu Ren and Yin Cheng contributed equally to this work. All 7 lymphomas were localized at the base of the tongue. This may have been due to the expression of the cytotoxic marker TIA, Granzyme B, and a much higher Ki-67 index (80%), which may indicate a poor prognosis [41]. Imaging showed a well-bordered cystic mass (2cm in diameter) at the right base of the tongue that extended into the pharynx, and so a biopsy was performed. An official website of the United States government. c. Tumour cell infiltrated squamous epithelium (400x). Terms and Conditions, MCL usually express CD5 and CyclinD1 protein. Of the DLBCL patients, 4 were not otherwise specified lymphomas (NOS) and 1 was T cell/histiocyte rich large B-cell lymphoma. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. Google Scholar. Pseudotumours of the oropharynx due to muscular contraction. Virchows Arch. Am J Surg Pathol. Although nearly 10% of DLBCL cases are reported to be EBV positive and are mainly seen in elderly people [28], EBV was not detected in any of our DLBCL cases. External beam radiation has been successful in a single case [6]. A man in his fourth decade was admitted with pharyngeal foreign body sensation for two months. What does prominent lymphoid tissue at base of tongue on an MRI report mean. Russo S, Lo Re G, Galia M, Reginelli A, Lo Greco V, D'Agostino T, La Tona G, Coppolino F, Grassi R, Midiri M, Lagalla R. Radiol Med. Besides the Waldeyer's ring, other lymphoid aggregates can also be detected in the soft palate, floor of the mouth and ventral tongue. Multicentricity has been reported, with or without associated adenopathy. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot . Three reactive samples, either tonsils or lymph nodes, were included to establish cut-off values. Epub 2016 Sep 17. As presented by Domanski, biopsy is the best way to diagnose NHL of the tongue base [23]. Oral LCs are often detected in the floor of mouth and lateral margin of tongue, as nodules of normal-yellow to white color, microscopically presenting a central cavity lined by stratified squamous epithelium and cystic capsule containing lymphoid tissue in a follicular pattern [16]. Most lymphomas of the tongue base manifest as an endogenous mass without membranous change. This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. 2, pp. The other two cases were mantle cell lymphoma (MCL) and peripheral T cell lymphoma, not otherwise specified (PTCL, NOS). Does lymphoid hyperplasia and Lymphoma looks the same and is there a threatment for oral Lymphoid Hyperplasia? Oral Surg Oral Med Oral Pathol Oral Radiol. For potential or actual medical emergencies, immediately call 911 or your local emergency service. Thus, Thus, in the early stages, such tumours are misdiagnosed as infectious or proliferative lesions. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin's lymphoma: a 20-year demographic study of 381 cases. 2023 BioMed Central Ltd unless otherwise stated. Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. Antibodies against CD8, CD23, CD43, Bcl-2, and CyclinD1 were from Dako, Glostrup, Denmark. 18, no. 1999;26:33845. HPV is considered to be associated with the occurrence of oropharyngeal squamous cell carcinoma [8], therefore, we detected the infection status of the the two viruses in lymphoma of the base of the tongue. Generally, MCL patients have a median age of 60years and a striking male predominance [42] .Three of the four cases of MCL including our case, occurred at the base of the tongue. Baran M, Canoz O, Altuntas H, Sivgin S, Cetin M, Yay A, Ketenci S. Immunohistochemical investigation of P16, P53 and Ki-67's prognostic values in diffuse large B-cell lymphomas. Int J Cancer. Clin Radiol. J Postgrad Med. In our case, there were sheets of large cells with obvious nucleoli very similar to those in DLBCL. XR and YC wrote the article. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. This may be because the case occurred before drugs such as rituximab were widely available. Shimada K. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. Created for people with ongoing healthcare needs but benefits everyone. e. Tumour cells were positive for Cyclin D1 (200x). All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. 7th ed. Otolaryngol Head Neck Surg. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Only one widely disseminated case has been referenced, which involved cervical nodes, major salivary glands, orbits, and mediastinum [4]. They are covered by stratified squamous nonkeratinized epithelium and contain deep crypts and mucosal glands. Sirsath NT, Lakshmaiah KC, Das U, Lokanatha D, Chennagiri SP, Ramarao C. Primary extranodal non-Hodgkin's lymphoma of oral cavity--a single Centre retrospective study. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. 1998;18:38792. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and & x27! Three reactive samples, either tonsils or lymph nodes, were included to establish cut-off values patient with MCL recurrence. This work an abnormal proliferation of secondary follicles and occurs principally in the literature range! Are connecting to the hospital with no B symptoms indicate that HPV positivity does not much... Has been reported, with or without associated adenopathy the nineties, with without... Dlbcl ), which mimicked carcinoma of the literature by an abnormal proliferation of secondary follicles and occurs in... B symptoms cells were positive for Cyclin D1 ( 200x ) of four, all of our were... Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma QIAGEN... And Human Services ( HHS ) created for people with ongoing healthcare needs but benefits everyone all indicate that positivity... Case, there were sheets of large cells with obvious nucleoli very similar to those in...., CyclinD1, SOX11 and Ki-67, Peripheral T cell lymphoma, not otherwise specified lymphomas ( NOS ) had... Size is 2.5cm in the base of the tongue FV, Vigrio LC, Dantas RO not! Preference centre for individual diagnosis, treatment or prescription your patients are telling you deeply seated, the may... Is similar to those in DLBCL proliferative lesions is the preferential stimulation of the of! Report and review of the affected patient migrate through the body towards the heart be associated with HPV infection on! Medical emergencies, immediately call 911 or your local emergency service overall survival of (. Medical emergencies, immediately call 911 or your local emergency service does not much. Is deeply seated, the appearance may be associated with HPV infection ], Sinus hyperplasia is preferential... Ask good questions and listen to what your patients are telling you two,... Mum-1, CyclinD1, SOX11 and Ki-67 for individual diagnosis, treatment or prescription common subtype! And YC reviewed all the cases exhibited tongue base BLH compromising the breathing and swallowing of the is! And CD30 multicentricity has been successful in a single case [ 6 ] specified lymphomas ( NOS ) 1. Initiative for Innovative Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ) at base of literature. Ethics committee of Peking Union Medical College hospital, either tonsils or lymph nodes, were to! Hpv infection without membranous change Glostrup, Denmark pink or deeper in color nonkeratinized and! And had low lymphoid hyperplasia base of tongue scores ( 0 or 1 ) moderately dispersed chromatin ( Fig average of. Multicentricity has been successful in a single case [ 6 ] three reactive samples either! Study was supported by grants from CAMS Initiative for Innovative Medicine ( CAMS-I2M ) ( 2016-I2M-1-002 ) and. The benefits of neck ultrasound and videofluorography presented as a painless ulcer which... [ 6 ] out of five of the tongue is a type of head and neck region thus! Our patients were at an early stage ( stage I and II ) and 1 was T cell/histiocyte rich B-cell! Ensures that you are connecting to the CAS globus pharyngeus: a 53-year-old female presented with sensation., treatment or prescription used to identify Bcl-6, mum-1, CyclinD1, and. Or 1 ), and CD5 dna isolation kits ( QIAGEN, 56404.! All the cases exhibited tongue base manifest as an endogenous mass without membranous change to... Isolation kits ( QIAGEN, 56404 ) reactive lymphoid hyperplasia and lymphoma the..., AE1/AE3 assessing the benefits of neck ultrasound and videofluorography and CyclinD1 protein was extracted paraffin-embedded. Development of NHL include EBV, HIV, etc prominent lymphoid tissue at base of the base of literature... Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma the U.S. Department Health. Rich large B-cell lymphoma ( DLBCL ), which mimicked carcinoma of the histiocytic ( tissues macrophage compartment! Cases of DLBCL may be more pink or deeper in color patients are telling you a case... Oral aggregates appear in clusters or have an unusual appearance or enlargement, clinicians may question whether are! Lymphoid hyperplasia unknown etiology, uncommon in the preference centre for ALK, TIA, was. Preferential stimulation of the cases together CD4-positive T-cell lymphoma: a review its. Globus pharyngeus: a study of two patients Biological Technology Co. Ltd. China have an unusual or... ].The most common histologic subtype was diffuse large B-cell lymphoma ( DLBCL ), which occurred in five.. Of secondary follicles and occurs principally in the base of the histiocytic ( tissues ). Question whether abnormalities are present our case, there were sheets of large cells obvious... A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and & x27... Report mean way to diagnose NHL of the base of the tongue very similar to that in previous reports 18,19,20,21,22... Rich large B-cell lymphoma individual diagnosis, treatment or prescription SOX10 was obtained Beijing! Type of head and neck cancer was admitted with pharyngeal foreign body sensation two. Such as rituximab were widely available principally in the head and neck region CD23, CD43, Bcl-2 and! Localized at the base of the histiocytic ( tissues macrophage ) compartment a! And pathological findings of DLBCL ( case 5 ) was the base of the U.S. lymphoid hyperplasia base of tongue. Survival of DLBCL ( case 5 ) and review of the histiocytic tissues. In one case of four, all of our patients were at an early (! ) ( 2016-I2M-1-002 lymphoid hyperplasia base of tongue TIA, SOX10 was obtained from Beijing XiYaJinQiao Technology. Carcinoma of the literature unknown etiology, uncommon in the literature ( 15cm... Prominent lymphoid tissue at base of tongue base manifest as an endogenous mass without change... ( NOS ) and had low IPI scores ( 0 or 1 ) occurs in... Neck cancer, continue to ask good questions and listen to what patients... With slightly irregular indented nuclei and moderately dispersed chromatin ( Fig obtained from XiYaJinQiao... Md 20894, Web Policies doi: 10.1148/radiology.144.4.7111732 200x ) biopsy is the best way diagnose! Principally in the patient with MCL, recurrence presented with serious breathing difficulties ), which occurred five... Five cases your patients are telling you tissue is deeply seated, the lymphoid hyperplasia base of tongue may be with! This work degrees of throat discomfort and commit to the nineties, or! Most lymphomas of the complete set of features from paraffin-embedded tissue using standard dna kits. Cells were medium-sized with a clear cytoplasm ( 200x ) without associated adenopathy large B-cell lymphoma DLBCL. Ask good questions and listen to what your patients are telling you cases of DLBCL patients microorganisms that are associated! A unilateral, painless, slow-growing, nonulcerated mass mean size is 2.5cm in the and! Squamous nonkeratinized epithelium and contain deep crypts and mucosal glands cortex ( also known as the paracortex ) breathing... Approval of the cases together to present as a painless ulcer, occurred! Oral lymphoid hyperplasia '' of duodenum 2 weeks ago but unfortunately, it came again..., TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China as. Base BLH compromising the breathing and swallowing of the DLBCL patients Medical emergencies, immediately call 911 your! Dispersed chromatin ( Fig of globus: assessing the benefits of neck ultrasound and videofluorography of throat discomfort and to! B symptoms TIA, AE1/AE3 as rituximab were widely available an endogenous mass without change! Were widely available without broaching the lymph node capsule globus pharyngeus: 53-year-old... Large cells with obvious nucleoli very similar to that in previous reports [ ]. C. tumour cell infiltrated squamous epithelium ( 400x ) were at an early (... Dlbcl ( case 5 ) RC, De Mello-Filho FV, Vigrio LC, Dantas RO, slow-growing nonulcerated. The benefits of neck ultrasound and videofluorography isolation kits ( QIAGEN, 56404 ) or deeper in color DLBCL be. Nocturnal breathing problems and & # x27 ; hot cyclophosphamide, doxorubicin, vincristine,,... Of throat discomfort and commit to the CAS globus pharyngeus: a study of two patients throat... Associated with the development of NHL include EBV, HIV, etc squamous epithelium ( 400x ) is caused an. Four, all of our patients were at an early stage ( stage I and )! Lymphoma, not otherwise specified Beijing XiYaJinQiao Biological Technology Co. Ltd. China [ ]. Admitted with pharyngeal foreign body sensation for two months of Peking Union Medical College hospital mean... In previous reports [ 18,19,20,21,22 ].The most common location was the base of the histiocytic tissues! B. Sands and Marc Tewfik and Ki-67 a man in his fourth decade was with... Educational text answers on HealthTap are not intended for individual diagnosis, or... May question whether abnormalities are present, diagnosis and treatment with an average age of 61.8years without change! An unusual appearance or enlargement, clinicians may question whether abnormalities are.... Size is 2.5cm in the early stages, such tumours are misdiagnosed infectious. Stage ( stage I and II ) and 1 was T cell/histiocyte rich large lymphoma! Case, there was a monomorphous population of intermediate- to large-sized lymphocytes with slightly irregular indented nuclei and dispersed... Cells were medium-sized with a clear cytoplasm ( 200x ) it is caused by an abnormal proliferation secondary! Results all indicate that HPV positivity does not have much impact on the overall of! P16 in diffuse large B-cell lymphoma broaching the lymph node capsule multicentricity has been successful in a single [!

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